 This study examined the potential of two types of colloidal silver nanoparticles, CSNPs those with quercetin and cafeic acid attached to them, CHU-CF-CSNPS, and those without CSNPs. The CHU-CF-CSNPS were shown to have a smaller particle size than CSNPs, and both types of particles had similar surface plasmid resonances at 417 and 424 nanometers. The CHU-CF-CSNPS also had a thicker chitosan layer around them compared to CSNPs, which could explain why they are more effective against cancer cells. Additionally, the CHU-CF-CSNPS demonstrated greater antimicrobial activity against gram-negative bacteria than gram-positive bacteria, while CSNPs did not show any significant difference between the two groups. This article was authored by Akif Hakenkert, Elif Berna Oludis, Fatma Opsioglu, and others.