 Welcome to our pre-filled series seminar, part three. My name is Klaus Ulhe, I'm a Senior Product Manager at Sünderkorn Technology in Kreisheim, Germany. Today, we want to talk about the first step in the filling line, the bag opening and the transfer into the sterile area. I'm very happy to have a guest here today, JP from Dupont, who will give us some insights about the bag itself and the Tyvek material. JP? Hi, my name is Juhabe Kapoor and I'm Technical Marketing Specialist for Tyvek Healthcare Packaging at Dupont. Thank you so much, Klaus, for having me. Yeah. Thanks, JP, for being here today. As you can see here, we have the bag opening machine that is doing the no-touch transfer of the tub into the sterile area, can be wraps or either isolator, and you see here the bag around the top, the top is inside and in the front, you see the waste bin where in the end, the empty bag is going. It is very important that we have a good fixation of the bag and we're doing that by the means of a vacuum suction from above and from below. Then the cutting takes place and the transfer of the tub into the sterile area takes place. Now I want to hand over to JP to give us some more insights about the bag itself and the material of Tyvek. JP? Let me first start by setting the context from my part. What we see here is so-called the bagging process where Tyvek pouch is removed from a tub containing ready-to-use preferable syringes. These ready-to-use preferable syringes are already washed, cleaned, and sterilized by the syringe manufacturer, and now pharma companies are using those pre-steralized syringes to package their drug products. This packaging we see here is only used in processes within the pharma companies. Now coming back to this de-backing process, also called no-transfer, as Klaus mentioned, this is actually really a well-researched proven GMB methodology for transitioning pre-steralized containers to create a clean room for filling. Essentially, this is basically removing packaging layers from the tub when moving towards more cleaner clean room environments. Yeah, this is exactly true, JP. So when all the discussions are taking place, this is a very important spot to transfer into the sterile area. It can be a wrap system. It can be an isolator system, JP. And the Tyvek part here, so Tyvek is used in the medical device packaging for a very long time and also in processes for pharma packaging needs. And Tyvek is composed of fine, interconnected, continuous filaments made of high-density polyethylene that are flas-pun into a non-movement structure. And it gives the really unique properties for in-process pharma packaging needs. Those are permeability to enable sterilization by ethylene oxide or steam gas. Low particle generation, obviously important for clean room environment. And micro-wheel barrier to maintain sterility after sterilization. And JP, what does it mean really for that packaging, for that bag that we see here in the movie? Yeah, so what we see here is a kind of 50-50 bag, if you will, consisting of Tyvek 1073B and impermeable transparent film. And having this large area of permeable Tyvek makes it ideal for exposing these syringes to ethylene oxide or steam sterilization cycles. So packaging is used to facilitate, know that's transfer process, meaning bags surrounding the tops are being removed progressively as the tops are transferred to more controlled areas inside the clean room. Thank you so much, JP. So we have learned a lot today. And for those who are watching the video, please give us your comments. Was it helpful for you? What do you want to see in the future? We would be happy about your feedback. See you soon.