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Published on Oct 4, 2013
Cascading flow and multi-organ device. An in vitro cell culture biodevice that consists of wells linked together through microfluidic channels and a syphon-drive system that controls flow through and between wells. The system allows for a "tempered" flow of chemical concentrations through wells either of a single lineage or between multiple lineages. The device advances nutrient transport for 'cells in system' approaches, and was designed to retain traditional culture configurations while advancing fluid distributions with grafted flow paths. This affords users the option to evaluate networked --cell, -tissue, and -environment relationships