Patient cancer cells help to test treatments
Organoids made of human tissue can predict patient response to drugs. For more see: http://www.sanger.ac.uk/new...
Organoids, small clusters of cells that accurately mimic the behaviour of human tissue, can be used to test cancer drugs and, eventually, to identify effective personalised treatments for patients.
Until now, cancer drug screening has primarily been carried out using two-dimensional cell lines grown in dishes, or in mouse models. Organoids, which more closely resemble human tumours than cell lines, and are less time and resource intensive than mouse models, offer researchers a middle ground between existing approaches.
These exciting findings are the result of an international collaboration involving the Sanger Institute and research teams in the UK, Netherlands, and the US .