Robert Furler O'Brien

In our laboratory, our central focus centers around exploring the intricate interplay between the three-dimensional cellular architecture and dynamic metabolic changes within T cells as they evolve over time. These transformations significantly influence crucial aspects like cell migration and effector functions. By delving into the metabolic and mechanical signals associated with HIV infection or HIV control, our mission is to unravel the underlying cytoskeletal re-arrangements, lipid vesicle trafficking, and chromatin accessibility that intricately shape T cell behavior. Through these comprehensive investigations, we aim to uncover fundamental insights that advance our understanding of T cell responses and contribute to the advancement of HIV research and immunology.  I'd love to hear from you﻿ through comments, email, or video responses.