 Arilamininacetyltransferase II, N82, is a phase II metabolic enzyme that is best known for its role in metabolizing aromatic amines and hygrosines. It has been found that individuals can be classified into three different categories based on their N82 activity level, rapid, intermediate, and slow acetylators. These groups differ greatly in their ability to metabolize certain compounds such as drugs and carcinogens. Non-coating or intergenic variants of N82 have been identified in multiple genome-wide association studies, GWAS, and have been linked to increased levels of plasma lipids and cholesterol. Furthermore, these variants have been shown to be associated with a faster N82 acetylation rate, suggesting that N82 activity may play a role in the development of dyslipidemia. This article was authored by Kyeong Yoo-hong, Kennedy M. Walls, and David W. Hine.