 This study found that a HBIG-free strategy was more effective than other options when implemented in an antiviral era. It showed that this strategy could meet the additional target for eliminating mother-to-child transmission of hepatitis B in resource-constrained settings, particularly those with a high HBSAG prevalence. This article was authored by Jareeporn Jantrapakti, Wirachadapangam, Pizzit Tank Advantage, and others.