 This article reviews the current understanding of how certain drugs, both synthetic and natural, can be used to treat cancer by inducing reactive oxygen species, ROS. These drugs include chemotherapy agents like Cisplatin and Doxorubicin, as well as phytochemicals and other small molecules currently under investigation for their anti-cancer properties. The authors discuss the mechanisms behind these drugs' ability to induce ROS and the subsequent effects of this process on cancer cells. Ultimately, they conclude that ROS induction is a promising approach for treating cancer, and that further research should be conducted to better understand its potential applications. This article was authored by Zora Noshinazami, Hanan Iyabirawi, Abdul Habib Simlali, and others.