 DOS, MCCPIK database of subnational economic output, is a comprehensive database of subnational economic output data, from 1,661 regions in 83 countries from 1960 to 2020. The data is derived from multiple sources including official statistics, e-books, and the literature, and is harmonized for both aggregate and sectoral output. Additionally, the data is spatially and temporally consistent, allowing it to be matched with geospatial data such as climate observations. This database provides researchers with the opportunity to conduct detailed analysis of economic development at the subnational level, consistent with reported values. This article was authored by Leonie Wenz, Robert Devon Carr, Noah Codgel, and others.