 This study found that the addition of a 4-quadrant trans-abdominal plane, 4-q-tap, blocked to the standard treatment of cytoreductive surgery with hypothermic intraperitoneal chemotherapy, CRS-Hypec, improved postoperative pain management by reducing the need for additional rescue analgesics and opioids. This suggests that the 4-q-tap block may be beneficial in improving postoperative outcomes following CRS-Hypec. This article was authored by Jaegyak Song, Nyang Choi, Minji Kong, and others.