 Curcumin-based hydrogel systems have shown promising antimicrobial and wound healing potential. This study demonstrated that the hydrogel had good physical properties and dissolved slowly over time, releasing curcumin into the environment. In vitro tests showed that the hydrogel was effective against both gram-positive and gram-negative bacteria, suggesting its potential use as an antibiotic agent. Additionally, in silico studies revealed interactions between curcumin components and key residues of inflammatory proteins, which could be beneficial for wound healing. Further in vivo testing is required to determine the clinical efficacy of this hydrogel for wound healing. This article was authored by Atesh Chopra, Shabana Bibi, Yughal Kashor Mohanta, and others.