 Inborn errors of immunity, IEI, are a group of rare genetic disorders that can cause serious health complications if left untreated. Currently, newborn screening for SCID is being conducted in some countries using a DNA-based test to measure T-cell, receptor excision circles, tracts, and capital-leading recombination excision circles, cracks, which can detect babies with this specific type of SCID. However, other types of IEI are not detected by this method. Therefore, upfront, first-tier genomic-based newborn screening should be considered as a way to simultaneously screen for hundreds of monogenic diseases at birth. Next generation sequencing could also be used to identify more types of IEI, but there are many ethical, legal and social considerations that need to be addressed before such a screening program can be implemented. This article was authored by Javanka R. King, Collie Grill, and Leonard Hammerstrom. We are article.tv, links in the description below.