 Epigenine is a natural compound found in many plants and fruits with potent anti-inflammatory, antioxidant, antimicrobial and anti-cancer properties. It has been shown to reduce inflammation, prevent oxidative stress and kill bacteria and viruses. Additionally, it has been observed to slow down the growth of tumors and promote apoptosis, cell death in cancerous cells. Furthermore, Epigenine has been found to target several key signaling pathways involved in cancer development, such as the PI3K, AKT, MAPK, ERK, JAK, STAT, NFB, and WNT-Catenin pathways. This review provides an overview of the latest research into the anti-cancer effects of Epigenine, as well as its potential applications as an adjunctive treatment for cancer patients. This article was authored by Siahu Yang, Miao Chi, Penfe Li, and others.