 Without the Holy Spirit, not only could you not be spiritual, you wouldn't even desire to be spiritual. For every spiritual desire comes from the Holy Spirit. Therefore, the desire to pray is itself an invitation to prayer. And not only does the Holy Spirit give you the desire to pray, He gives you the ability to pray. Truly, the Holy Spirit helps you pray. And the Holy Spirit helps us in our weakness. For example, we don't know what God wants us to pray for, but the Holy Spirit prays for us with groanings that cannot be expressed in words. That's Romans 8, 26. So when you don't know what to pray and if you don't know how to pray, ask the Holy Spirit to guide you. The guidance of the Holy Spirit is the key to true and effective prayer.