 Thank you very much and thanks, of course, to the Brand Foundation and all the Donor for a You really mean a lot as an early career researcher to get our first funding. So thank you very much So Cerebral small vessel disease is a common feature of the aging brand. So basically is a small brand blood vessel of the brain who get damaged With the aging process and this has been associated with a very strong increasing risk of dementia and increased risk of stroke and Currently, there is no cure treatment for this disease The main approach for the treatment is simply to manage the risk factor So for example people with a patient who have obstructive sleep apnea they tend to develop Blood brain damage and this is a consequence of the apnea that they have during sleep so people with obstructive sleep apnea generally they have a A closure of the upper way when they sleep and if you want this decrease The air flow so they have oxygen dissaturation in the blood And this combined with a small surge in blood pressure at the end of the apnea damage or the blood vessel So this part is this patient are very high risk to develop blood brain damage and on long-term development of cognitive impairment And this is in Australia there is a large proportion of the population who have obstructive sleep apnea And this prevalence is even increasing as the population become more obese So this is a very important for the health problem for the australia However, the good news is if we detect and diagnosis this brain change very early on We know that we can reverse this damage. The problem is currently We rely on imaging technique for the development or the diagnostic of the brain damage But there is no really Ideal imaging technique to develop the early brain damage So at this stage using a routine MRI scan we can only In obstructive sleep apnea patient detect brain damage when it's almost too late to get any reverse change with Treatment management So the aim of this project is really to develop a new advanced MRI imaging technique that we be able to detect the early change occurring in the brain to Hopefully and we expect really improve the disease diagnostic but also improve the treatment strategy So for this model we want to work with patients with obstructive sleep apnea But we really expect our research could be expanding to others population I have in mind a patient with cardiovascular disease in particular who are also at high risk of developing Blood damage in the form blood vessel damage in their brain So, um, thank you very much for your support and uh, I hope we will Make the burn formation very proud Thanks