Video Synopsis: Christian Lange, Peter Carmeliet & colleagues

EMBO Press
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Published on Jan 19, 2016

Blood vessel formation in mammalian brain development promotes neural stem cell differentiation by triggering a cascade of tissue oxygenation, reduced activity of HIF-1α and blunted glycolytic metabolism that favors the switch towards neurogenesis.

Original article: http://emboj.embopress.org/content/ea...
The EMBO Journal

Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis

Christian Lange, Miguel Turrero Garcia, Ilaria Decimo, Francesco Bifari, Guy Eelen, Annelies Quaegebeur, Ruben Boon, Hui Zhao, Bram Boeckx, Junlei Chang, Christine Wu, Ferdinand Le Noble, Diether Lambrechts, Mieke Dewerchin, Calvin J. Kuo, Wieland B. Huttner & Peter Karmeliet

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