 Pancreatic cancer is one of the most difficult types of cancer to treat due to its resistance to chemotherapy. Researchers have found that forcing the body into a hypoglycemic state can significantly increase the effectiveness of chemotherapy for treating pancreatic cancer. This is because the hypoglycemic state reduces the amount of glutathione produced by cells, which increases the amount of oxidative stress on the cancer cells, making them more susceptible to chemotherapy. Additionally, blocking the production of glutathione can also mimic the effects of the hypoglycemic state, further increasing the effectiveness of chemotherapy. This article was authored by early Vizirigoha, Jonathan J Hu, Atta Abbas, and others.