 Nanoparticles have become increasingly important in the field of medicine due to their ability to target specific areas of the body and deliver drugs or imaging agents. Over the past five years, several nanoparticle-based products have been approved for use in the clinic, including the COVID-19 vaccine. Additionally, many new clinical trials have been initiated using nanoparticles, such as those involving the treatment of cancer and other diseases. This article was authored by Aaron C. Anselmo and Samir Mitragotri.