 This study proposes a novel strategy using ultrasound, U.S., and piezoelectric SNS nanosheets to generate hydrogen and deprive lactic acid in deep tumors, which activates CD8 plus T cells and achieves high efficacy in liver tumor therapy with complete tumor eradication and 100% miceurvival. This article was authored by An Bang Wu, Ling Dong Zhang, Chao Xia, and others.