 The occurrence of diabetic foot ulcers, DFUs, is increased due to an aging population and changes in dietary habits. DFUs can lead to serious disabilities, reduced quality of life, and high financial costs for society. Understanding the pathophysiology of DFUs, which involves metabolic dysfunction, diabetic immunopathy, neuropathy, and angiopathy, can help prevent and manage them more effectively. The suppression of endothelial nitric oxide production leads to microcirculation atherosclerosis, heightened inflammation, and abnormal intimal growth. Directly addressing the pathogenesis of DFUs could pave the way for innovative treatment approaches that can prevent serious complications such as major amputations. This article was authored by Jion Kim.