 Nanotechnology has the potential to overcome many of the limitations associated with traditional treatments for cancer. Significant advances have been made in developing nanomaterials that can target cancer cells specifically while also delivering drugs more efficiently than conventional methods. These nanomaterials can be tailored to increase drug loading, improve half-life in the body, control release, and even selectively distribute them within the body. Polymeric nanomaterials, metallic nanoparticles, carbon-based materials, liposomes, and dendramas have all been developed as smart drug delivery systems for cancer treatment, offering enhanced pharmacokinetics and pharmacodynamics compared to conventional formulations due to their small size and unique physical and chemical properties. The data presented in the literature suggests that nanotechnology will play a key role in the development of new cancer treatments and anti-cancer therapies. This review summarizes the progress made so far in nanomaterial engineering for cancer therapy, including strategies for targeting and releasing drugs for effective cancer administration. It also highlights some of the challenges associated with nanotoxicity, which is often... This article was authored by P. N. Navya, Anubhav Khaful, S. P. Srinivas, and others. We are article.tv, links in the description below.