 The results of this study suggest that the thrombodynamics test can be used as a reliable tool to measure the effects of direct oral anticoagulants, dokes, on thrombus characteristics in patients with atrial fibrillation, AF. The test showed that all parameters of thrombodynamics test taken at residual concentration of dokes were within reference values, indicating that these drugs have an effective anticoagulant effect. Furthermore, the obtained data of normal coagulation at the residual concentration of the anticoagulant are consistent with the previously obtained data on the safety and effectiveness of dokes using other methods. This article was authored by Z. A. Gebikova, I. I. Ivanov, A. Asambaeva, and others.