 This study, NCT 01235949, assessed the immunogenicity of P-hydCV following prophylactic ibuprofen administration in healthy infants during primary and booster doses, demonstrating non-inferiority to no ibuprofen or paracetamol administration for seven-tenths vaccine serotypes. However, fever incidence post-primary vaccination was not significantly reduced by prophylactic ibuprofen or dibu. Paracetamol decreased fever incidence, but seemed to reduce immune response to P-hydCV, except when given only at booster. This article was authored by owner Philip Peccurario, so in Seaman, Mihail Nintu, and others.