 The L1-retrotransposin is a major component of the human genome, accounting for approximately 17%. It contains two proteins, ORF1P and ORF2P, which are essential for its movement from one cell to another. ORF1P is a trimeric-RNA binding protein that forms a structure that allows it to interact with the RNA of the L1-retrotransposin. This interaction is important for the formation of an L1-INP condensate, which is necessary for the retrotransposition process. Mutations that disrupt this interaction result in a decrease in retrotransposition activity. Additionally, ORF1P's dynamic oligomerisation on the L1-INA is thought to be responsible for the formation of the L1-INP condensate. This article was authored by Shrinjoy Sill, Sarah Keegan, Farida Etifa, and others.