 This research has developed a novel approach to detecting changes in glucose and hydrogen peroxide levels using a porous two-dimensional conductive metalorganic framework, CMOF. The CMOF was created using a one-pot method and then applied to create enzyme-free paper-based electrochemical sensors using screen printing and inkjet printing techniques. The resulting sensors were able to accurately measure both glucose and hydrogen peroxide levels with low detection limits and high sensitivities. Additionally, these sensors were able to distinguish between human serum and artificial sweat samples, demonstrating their potential for future applications in the design and development of new multifunctional and high-performance flexible electronic sensors. This article was authored by a young, Wen Wei Ji, Yu Tao Yin, and others.