 The study found that Zip10 is a key regulator of zinc transport in hematopoiesis, and its absence leads to a more severe form of impaired hematopoiesis than animals lacking transferrin receptor 1, a known iron gatekeeper. It was also discovered that Zip10 is essential for maintaining zinc levels in fetal hematopoietic stem cells, HSEs, and that zinc supplementation can restore colony formation in HSEs derived from hematopoietic SLC39, a 10th deficient mice. Additionally, the study showed that Zip10 protects against zinc deficiency-induced necrophotosis, suggesting that it could be used as a potential therapeutic target for treating anemia and other zinc deficiency-related diseases. This article was authored by Xi'en He, Chowdongu, Juncia, and others.