 The study found that whole-body cryotherapy combined with therapeutic exercises significantly reduced low back pain in patients with lumbar spine osteoarthritis, while also inducing hormonal adaptations such as increased cortisol and adrenaline levels, but no statistically significant change in beta-endorphin levels. This article was authored by Marta Barlos-Katribulek, Claudia Zawajska, Joanna Sklarksyk, and others.