 Recent health emergencies like COVID-19, Mpox, and Ebola, as well as other zoonotic diseases like rabies, some vector-borne diseases such as yellow fever, and other threats like antimicrobial resistance and foodborne diseases all illustrate the strong relationship between the health of humans, animals, plants, and the environment we share. For instance, around 75% of all emerging infectious human diseases originate in animals. Human activities, including irresponsible land use and deforestation, result in people and domestic animals encroaching into wild areas. This increases the risk of new or reemerging pathogens spilling over between wildlife, domestic animals, and humans. Many other factors can affect the distribution of diseases. The climate crisis has led to unpredictable and extreme weather events like floods, droughts, and wildfires, with a huge impact on animal, human, and plant populations, and the environment itself. Similarly, biodiversity loss undermines the ecosystem's ability to mitigate the spread of infectious diseases across species. Collaboration across sectors and disciplines through a one-health approach is a vital need for addressing the complex health challenges facing our society. No one organization can do it alone. Therefore, the Food and Agriculture Organization of the United Nations, the UN Environment Program, the World Health Organization, and the World Organization for Animal Health have come together as a quadripartite. They have launched the One Health Joint Plan of Action to integrate and coordinate strategies and actions across the human, animal, plants, and environmental sectors. This new plan focuses on supporting and scaling up countries' capacities in six main areas. Health systems, zoonotic diseases, neglected tropical and vector-borne diseases, food safety, antimicrobial resistance, and the environment. It promotes the health of humans, animals, plants, and the environment by providing guidance and tools to coordinate multi-sectoral approaches to prevent and manage health risks at the human, animal, plant, environment interface. There is only one planet and one health. Together, we can build a safer, healthier, fairer, and sustainable world for all.