 We conducted an observational retrospective study on patients hospitalized with COVID-19 during March 5, 2020 to October 28, 2021 and developed an agent-based model to evaluate effectiveness of recommended healthcare resources, hospital beds and ventilators, management strategies during the COVID-19 pandemic in Gauteng, South Africa. We measured the effectiveness of these strategies by calculating the number of deaths prevented by implementing them. We observed differences between the epidemic waves. The length of hospital stay, LOS, during the third wave was lower than the first two waves. The median of the LOS was 6.73 days, 6.63 days, and 6.78 days for the first, second and third wave, respectively. A combination of public and private sector provided hospital care to COVID-19 patients requiring ward and intensive care units, ICU beds. The private sector provided 88.4% of high care, HC, slash ICU beds, and 49.4% of ward beds, 73.9% and 51.4%. This article was authored by Manas Alavinejad, Bruce Malato, Ali Asgari, and others. We are article.tv, links in the description below.