 Glucocorticoid preparations, such as adrenocortical steroids, have strong anti-inflammatory and immunosuppressive effects. These medicines are widely used for treating various diseases. Patients who receive steroid therapy prior to surgery may require additional doses of glucocorticoids to cope with the increased cortisol demand caused by surgical stress. Textbooks and research articles suggest that glucocorticoids should be administered in an amount equivalent to about 100 milligrams of cortisol for major surgeries. More studies are.