 Aeromonas hydrophila is a common fish pathogen and an opportunistic human pathogen. It can be found in aquatic environments as well as in food and bottled mineral waters. It causes hemorrhagic septicemia, ulcerative disease and motile aeromonas septicemia, MAS, in fish and other aquatic animals. Additionally, it may lead to gastroenteritis, wound infections and septicemia in humans. Variables such as virulence genes, host susceptibility and environmental stresses affect the severity of the illness caused by this pathogen. Identifying virulence factors in A. Hydrophila could help develop prevention and control measures. 95 different species of aeromonas were analyzed in the current study and 53 strains were confirmed to be A. Hydrophila. These genomes were compared to determine if they shared any similarities. The pan and core genomes of A. Hydrophila were examined using a comparative genomics approach. The pan genome was found to contain 18,306 total genes and 1620 gen. This article was authored by Baha Abdelah, Nohane Abazzara, Nomeen Mshokra, and others. We are article.tv, links in the description below.