 Good morning faculty members, respected delegates, I am Dr. Sushmit Afle, 3rd year resident from DIY particle medical college, Navi Mobile. Today's my title is muco-microcytes in COVID-19, it's a systemic review of cases reported in DIY particle hospital in correlation with the co-morbidity. Coronavirus disease is caused by the severe acute respiratory syndrome, coronavirus 2, it has been associated with wide range of opportunistic bacteria and the fungal infection. Muco-microcytes is a spectrum of invasive fungal infections that is caused by the mucarils, order that belongs to the surfylon, muco-microtina, rhizoporus, mucar, rhizomucar and the leastimia. It has been associated with the wide range of opportunistic bacteria and the fungal infections. This fungi may present in a wide range of multiple clinical syndromes with sinuses, orbital, cerebral, pulmonary and the gastrointestinal involvement. The germinate forming angioinvasive hyphae that was in function of the involved tissue giving in a dry gangrene appearance, the angioinvasive capability of the organisms that can lead to direct infiltration to the blood vessels and the thrombosis or embolism at present as acute ischemic stroke. Several risk factors are described including the diabetes malitis, malignancies, solid and the bone marrow transplantation, iron overload status, steroid mediated or background cohabititis. Other shared risk factors includes prolonged hospitalization with or without mechanical ventilators. Diabetes malitis stand as the strongest risk factors giving rise to the 36% of patients with invasive muco-microcytes where diabetes in present cases reviewed in 929 cases. While long-term use of corticosteroids have often been associated with several opportunistic fungal infections that includes the asperagealysis and the muco-microcytes, even a third course of corticosteroids has recently been associated with muco-microcytes especially in people with diabetes malitis, aims and objectives, aims to know its temporal association in relation to comorbidities and with drugs being used in the COVID-19. Objectives to analyze the patient characteristics associated comorbidities, location of muco-microcytes, use of corticosteroids and its outcome in patients with COVID-19. Materials and methods patients present with the COVID-19 positive status with comorbidities, COVID-19 positive status with periorbital and facial swelling, case presentation, case for, or 60 years old diabetic male presented with respiratory distress, left orbital pain and swelling, left nasal congestion and discharge with fever of short duration. RT-PCR from the nasopharyngeal swab for COVID-19 was positive. Here on the axial images, left etymodal sinusitis with ill-defined medial wall of the left orbit and hypoenzymes foci are also seen involving the flow of orbit with this discontinuity. Case two, a 40 years old female presented with right orbital pain and swelling for five days. Patient had passed history of severe COVID pneumonia for which she was hospitalized three weeks ago. She was treated with remdesivir, oxygen support and intravenous methylprednisolone. On axial and coronal images, polypoidal mucosal thickness is seen involving the bilateral maxillary, etymoid, spinoid and the frontal sinuses with smooth expansion of the sinuses. On coronal image, the extra coronal muscles and the retroorbital it shows T1 hyperintense and T2 hyperintense areas within the purposes of the right glom. Case three, a 51 years old male presented with right sided weakness for seven days. RT-PCR from the nasopharyngeal swab was positive. Here, the polypoidal mucosal thickness is seen involving the left maxillary, etymoid and the frontal sinuses with T2 hypointense areas within. On coronal section, the few areas of cortical bridge are also seen involving the left riviform plate with suspicious intranational extension of the legion. Areas of ultrasonic signal intensities appearing as hypointense and T1 and hyperintense and T2 involving the anterior inferior and the basic frontal region and crossing the midline. Histopathology evaluation of the nasal discharge reveals broad aseptic like fungi hyphae on QH weight more. Case four, a 45 years male presented with respiratory distress and pain in abdomen since one week. RT-PCR from the nasopharyngeal swab was positive. On axial images, there is circumferential wall thickening of the terminal ilium, illusical junction and the wheat mite adjacent phytostanding. Here on the coronal images, there is circumferential wall thickening of the terminal ilium, illusical junction with mild adjacent phytostanding. Discussion. Mucomycosis is an opportunistic fungal infection which causes angioinvasive disease leading aggressive lacrosis and infarction of the involved tissue. Rhinoorbital mucontagusis involves the parancel sinuses and orbit orbits and may extend into the cerebral paranthema. Underlying feed supposing factors that includes the uncontrolled diabetes malignness, immunocompromis status, systemic use of corticase steroids, pre-existing respiratory pathology, cancers and steam cell transplant. Among these, diabetes is one of the most common etiology. Results. In a recent systemic review conducted until 2020, almost 2021, out of 27 cases, 21 had involvement of the parancel sinuses and 4 had extension of infection into the orbital compartment, one with the intracranial extension and one with the extension into the gastrointestinal tract. The findings of 27 suspected mucomycosis cases in people with COVID-19, diabetes malignness was reported in 70.3 cases while 88.8 were receiving the corticosteroids. These findings are consistent with the case series of 27 suspected mucomycosis in COVID-19. The 69% had the diabetes malignness and more than two-third deceives the corticosteroids. Collectively, these findings are familiar at the familiar connection of mucomycosis and the corticosteroids induced in patients with COVID-19. Conclusion. Imagining findings of the mucomycosis includes the mucosal thickening or the obfuscification of the involved parancel sinuses. Majority of the lesions that appear hypotensin T1 and variable to hyperintensin T2 images. Low signal intensity of the fungal elements on T2 vented images along with restricted diffusion on the DWI may be seen. Hypertrophy of the nasal terminus with the nasal secretion is seen with the nasal involvement. Discontrast enhancement can be seen in the thickened mucosa and involved tissue. However, the areas of non-enhancing soft tissue may be seen within the affected corbinates or the paranasal sinuses and it's also known as the black-corbinate sign. Designs helps in the early detection of the nasal mucomycosis. Thank you.