 This research suggests that the combination of carboplatin and tryptolide may be effective in treating melanoma. Tryptolide was found to inhibit the N-R pathway, which is important for DNA repair, and when combined with carboplatin it had a synergistic effect on cell viability, migration, invasion, and apoptosis. Additionally, this combination therapy was shown to reduce tumor growth in nude mice. This article was authored by Gungwang, Hongmingwa, Yenrun, and others.