 This study examined the association between certain patient characteristics and the risk of experiencing an outpatient parenteral antimicrobial therapy, OPAT, complication. The results showed that patients discharged to a subacute rehabilitation center, SARC, were more likely to develop a central line-associated bloodstream infection, CLABSI, as well as being readmitted for OPAT complications. Additionally, loss to follow-up with the infectious diseases service was also associated with increased risks of CLABSI and 30-day readmission. These findings suggest that further efforts are necessary to reduce the risk of OPAT complications among patients discharged to SARCs.