 Bioactive glasses have had a significant impact on the field of regenerative medicine. Invented by Larry Hench in 1968, the original 45S5 glass composition has been used in millions of patients worldwide to treat bone and dental defects. Since then, numerous other bioactive glass compositions have been developed and tested for various medical applications, including soft tissue repair and drug delivery. Despite these advances, there is still much to be discovered and explored in terms of bioactive glasses potential. To address this, researchers must collaborate across disciplines, combining expertise from glass chemistry, bioengineering, and clinical practice. This paper discusses six key areas where further research is needed to fully realize the potential of bioactive glasses in medicine. This article was authored by Francesco Baino, Sapita Hamzola, and Saeed Kargozer.