 Imagine a world where diagnosing an illness is as simple as getting blood drawn, where diseases can be targeted by medicines with pinpoint accuracy, where drugs are perfectly tailored to a patient's genetic makeup and produce no side effects. This world is the promise of precision medicine. And with the growing ease with which personalized health information can be collected, many believe now may be the best time to start delivering on that promise. At Precision Medicine 2016, a virtual conference hosted by lab roots, experts from industry, academia and government discuss the recent advances in bioscience and clinical medicine that are laying the groundwork for this exciting endeavor. At the forefront of these efforts is the Precision Medicine Initiative. Announced in 2015 during President Obama's State of the Union address, this initiative calls for $215 million in funding for the research and infrastructure needed to support the development of personalized medicine. The last decade has witnessed impressive advances in DNA sequencing, computational biology, biomarker detection and rational drug design. And today, more people are engaging in improving their health and participating in health research than ever before. To build on this momentum, the Precision Medicine Initiative calls for, among other developments, the creation of a national research cohort of one million volunteers. The medical information shared by this large group will help researchers discover new connections among environmental factors, genes, disease, and therapeutic responses. Keynote speaker Dr. Eric Schatt, professor of genomics at the ICON Institute for Genomics and Multiscale Biology, discusses what scientists can do with the universe of data collected from individuals. Capitalizing on the rapid advancement of medical diagnostic technology and the growing popularity of wearable sensors and mobile apps designed for health management, scientists can aggregate massive amounts of data to create predictive models of disease. These models, Dr. Schatt says, can lead to better diagnoses and treatments for common and rare human diseases. The presenters at Precision Medicine 2016 approach the refinement of medical treatments from many angles, from the technical and organizational challenges of sequencing the genomes of many volunteers, to the computational challenges of accessing and analyzing these vast datasets, to the design challenge of creating treatments that interact with cells and proteins in desirable ways. Together, the presenters and participants of Precision Medicine 2016 are paving the way to a true revolution in medicine and health.