 The IMO decarbonization roadmap requires a complete rethinking of the way ships are designed and operated. This includes the development of new technologies, such as ammonia-powered vessels, which can reduce GHG emissions while maintaining efficiency. To achieve this goal, a comprehensive approach is needed, including the use of advanced computational tools like KEEZES, which can be used to optimize the design of these vessels and their propulsion systems. This article was authored by Lampros Nikolopoulos and Evangelos Bola-Guriz.