 Set is a protein involved in the regulation of genetic expression. In individuals with the Schindsel-Gedian syndrome, SGS, there is an excess of set protein, resulting in a maladaptive mechanism that leads to the rewiring of the distal control of gene transcription. This results in a less precise differentiation of cells, which can lead to various health complications. This article was authored by Matthias Agui, Federica Banffi, Luca Massimino, and others.