 An exploratory pilot descriptive research study was conducted in rural counties of Henry and Glades, Florida, exploring parental knowledge and hesitancy towards HPV vaccination among parents, caregivers with children aged 9 to 13. Using quantitative methods, we evaluated their knowledge, feelings and beliefs about HPV vaccination, including vaccination prevalence and correlates. Our measures included the parental HPV survey with a chron batch as alpha of 0.96. Results reveal that 26% of parents showed caution due to stigma around vaccination while attributing low levels of knowledge about HPV vaccination. 80% had a persistent belief that HPV vaccination could leave their child sterile, perpetuating hesitancy. Parents with a high school education or less and conservative religious affiliation did not decline HPV vaccination. To increase HPV vaccine knowledge and decrease hesitancy, interventions such as increasing public education with community input and a focus on cultural norms in each specific rural community among parents and providers are needed. This article was authored by Tammy L. Thomas, Michelle Caldera and Jeffrey Mauer. We are article.tv, links in the description below.