 This study investigates whether there are differences in the response to antioxidants between males and females when exposed to gentamicin-induced nephrotoxicity. The results showed that both vitamins E and C had protective effects against gentamicin-induced nephrotoxicity in both genders. However, the protective effects of vitamin E were more pronounced in female rats than in males. This article was authored by Tahira Safari, Sade Miri, Olmed Goughran, and others.