 Abstract tomato is the most valuable fruit and vegetable crop worldwide, but it contains a toxic compound called alpha-tomatine. However, this compound can be converted into a non-toxic form called isculiocide A through a series of chemical reactions. These reactions are catalyzed by a specific enzyme, which has not yet been identified. In this study, researchers found that a gene called Game 36 is responsible for catalyzing these reactions in both cultivated and wild tomatoes. This discovery allows scientists to use genetic engineering to produce isculiocide A in other plants or microorganisms, which could lead to new applications such as improved flavour and nutrition in tomatoes. Additionally, the researchers believe that the presence of this gene in tomatoes may have played a role in their domestication and improvement over time. This article was authored by Prashant Desonawayne, Sachin Agart, Adam Joswiak, and others.