 Deferoxamine, DFO, loaded black phosphorus nanosheets decorated by polydopamine layer are prepared and compounded into gelatin methacrylate-slash-sodium-alginate-methacrylate-GA, hybrid hydrogel, as a smart responsive therapeutic system for accelerated bone regeneration. The BP-PD nanocomposites served as bioactive components and near-infrared, NIR, photothermal agents, which conferred the hydrogel with excellent NIR-slash-PH dual-responsive properties, realizing the stimuli-responsive release of DFO and PO-43- during bone regeneration. Under the action of NR-triggered mild photothermal therapy, the GA-slash-BP-PD hydrogel exhibited a positive effect on promoting osteogenesis and angiogenesis, eliminating excessive reactive oxygen species, and inducing macrophage polarization to the M2 phenotype. Through macrophage M2 polarization-induced osteoimmune microenvironment, this hydrogel platform could also drive functional cytokine secretion for enhanced angiogenesis and osteogenesis. In vivo experiments further demonstrated that the GA-slash-BP-PD system could facilitate bone healing by attenuating the local inflammatory response, increasing the secretion of pro-healing factors, stimulating endogenous cell recruitment, and accelerating revascularization. This article was authored by Minheil Wu, Huifan Lu, Dan Li, and others. We are article.tv, links in the description below.