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Published on Feb 15, 2016
Table of Contents: 00:09 Lecture 5.4: Concluding Thoughts 00:48 Outline 01:35 Why nano-biosensors 04:22 A short history of the three sensors 06:23 Geometry is the key for nanobiosensing 07:58 (A) Settling Time: A 'Mendeleev Table' 09:16 Strategies to Beat the Diffusion Limit 11:50 (B) Three types of sensors 12:32 Improving the sensitivity limits 16:43 (C) Selectivity Classified 18:59 Improving Selectivity 20:30 Sensors not discussed: Optical Sensors 22:22 Optical Sensors 23:35 Outline 23:46 Lab on a chip: pH-based genome sequencer 24:24 Promise of nanobiotechnology 25:19 Conformal Electronics and Smart Bandages 25:59 Implanted Sensors: Heart 26:37 Sensing and actuation 27:46 Sensing and actuation: Optogenetics 28:42 Outline 28:56 A sensor as a biomimetic device 30:12 Form Defines Function 30:47 Landscape of Electronics 31:45 Conclusions 34:08 Acknowledgement
This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.