 Bioactive peptides derived from fish protein hydrolysis have been identified and studied for their potential applications in food and pharmaceutical industries. These peptides exhibit a variety of beneficial properties, including antibacterial, antifungal, anti-cancer, anti-diabetic, and antioxidant activities. Enzyme-based hydrolysis is the most common method used to prepare these peptides, but its high cost and limited availability of food-grade enzymes limit its application. Recently, researchers have focused on developing more efficient and cost-effective methods for the production of bioactive peptides from fish protein hydrolysates. This article was authored by Ressa Grace-Guanga Ortizzo, Vishal Sharma, Meiling Tsai, and others.