 the intestine has a unique ability to regenerate itself quickly due to its fast cycling stem cells. These stem cells are controlled by a mosaic pattern at their base, which is maintained by a complex network of signals. A new study suggests that the stem cells use a positive feedback loop to maintain their mosaic pattern, which helps them respond quickly to changes in the environment. By disrupting this feedback loop, researchers were able to alter the mosaic pattern and reduce the organ's ability to regenerate. This study provides insight into how the intestines can be better understood and manipulated for therapeutic purposes. This article was authored by Kaiyuan Chen, Tara Shrinivasan, Kuei Lingting, and others.