 Hello, my name is Gareth Bainam and I'm a clinical geologist at Genetic Services in Western Australia. I had a great pleasure today to introduce an article that was put together by a team of individuals which are the fortune to represent and it's published in the journal Human Mutation and it's entitled The Facial Evolution Looking Backwarder Moving Forward. As a clinical geologist I spend a large proportion of my working day trying to interpret subtle facial clues to help make a diagnosis to ultimately facilitate timing medical intervention. I first became interested in this exoding technology whilst following the work of many other scientists and clinicians around the world. And then more locally, watching the application of this technology within the clinical workflow in our Craniomaxilla Facial Union. In this article we look backward to review how facial evolution may influence and instruct the application of 3D facial analysis. And then we move forward to review some aspects of 3D facial analysis to specifically focus on its application in rare diseases as to the one in 12 individuals living with a rare disease and including diagnostics, screening, surgical planning and audit and perhaps even treatment monitoring. We propose, as has been suggested by others, that this work will be best progressed by innovative, collaborative, nodal and global networks. I really do hope you enjoy reading our article, The Facial Evolution Looking Backwards and Moving Forward. Thank you.