 Poly, anisopropylacrylamide, PNIPAM, hydrogels are being increasingly used in biomedical applications due to their unique properties such as temperature-sensitive swelling behavior, tunable mechanical properties, and high water content. These properties can be further enhanced by incorporating other polymers such as poly, ethylene glycol, PEG, and or poly, epsilon caprolactone, PCL. Additionally, biopolymers such as collagen and hyaluronic acid can also be used to improve the biocompatibility of these hydrogels. Furthermore, advancements in three-dimensional bioprinting technology will enable the development of novel medical devices and tools with temperature responsive properties. This article was authored by Sonia Lanzalaco and Delayne Armelen.