 Metal 13 is a tumor suppressor gene that is down-regulated in bladder cancer cells. This leads to reduced cell proliferation, decreased phosphorylation of RB, and delayed cell cycle progression. Additionally, it also inhibits cell migration and invasion through down-regulation of FAK, AKT, catenin, and MMP9. This article was offered by Zhejiang, Guozhuangjiang, Chuhaiskong, and others.