 Impaired cerebellar development of premature infants and the associated impairment of cerebellar functions in cognitive development could be crucial factors for neurodevelopmental disorders. Additionally, anaesthetic and hyperoxia-induced neurotoxicity of the immature brain can lead to learning and behavioral disorders. To address these issues, dexmodetomidine, DX, which has been shown to have neuroprotective properties, was administered to six-day-old Wisterats, P6. After exposure to hyperoxia, 80% O2, or normoxia, 21% O2, for 24 hours, DX was administered to the animals. At P7, P9, P11, and P14, the cerebellum was examined for changes in perkinge cells and other markers of cellular damage. DX protected perkinge cells from hyperoxic injury and modulated neuronal transcription in the short term without any effects at the cellular level. Furthermore, DX appeared to differentially affect cerebellar granular cell neurogenesis following. This article was authored by Robert Pulse, Clarissa Vaughan, Christoph Burer, and others. We are article.tv, links in the description below.