 This study investigates a Neosteoarthritis, KOA, which is characterized by degeneration of articular cartilage. Two key mechanoregulatory factors, strain in collagen fibral direction, SFD, and maximum shear strain, MSS, were assessed using a combination of musculoskeletal and finite element modeling. The results showed that both SFD and MSS factors could distinguish between a healthy subject and a KOA subject, indicating progression at two years follow-up. Additionally, the authors identified that the tibial compartment of the KOA subject had higher SFD and MSS values than the healthy subject. This suggests that the tibial compartment of the KOA subject may be at greater risk of progression. This article was authored by Ikram Mohaut, Syed Ali-Elahi, Syed Ali-Elahi, and others.